Since 1958, we have confronted the world’s greatest health challenges and daunting emergencies. We have responded to hurricanes and earthquakes and the humanitarian consequences of civil war. We were on the frontlines of an Ebola outbreak in Africa and rebuilt creaking public health networks in the Soviet bloc during the Cold War and after the Iron Curtain fell. When deadly tsunamis hit Japan and Southeast Asia, Project HOPE was quick to deploy and stayed for months. We have built health systems from the ground up and repaired others in the developing world, building a legacy of functioning health infrastructure that will endure for generations. Two million trained health care workers around the world and many hospitals, from Asia to Africa and Central America to Eastern Europe, bear witness to HOPE’s legacy of care.